Long forms of cardiac troponin T for myocardial infarction diagnosis: the SuperTROPO study.

ABSTRACT:

Background and aims

Elevated cardiac troponin levels are a frequent finding in emergency department patients, often without a clear cause. Current high-sensitivity cardiac troponin T (cTnT) assays measure intact and fragmented cardiac troponin T (total cTnT) molecules, without distinguishing between them. This study investigated whether measuring only intact and minimally fragmented cTnT (long cTnT) provides additional value for myocardial infarction (MI) identification.

Methods

Consecutive emergency department patients with standard high-sensitivity cTnT levels (Roche Diagnostics) above the upper reference limit (≥14 ng/L) were recruited. Long cTnT levels were measured using a novel immunoassay. The additional diagnostic value of long cTnT in identifying patients with type

SUBMITTER: Teppo K 

PROVIDER: S-EPMC12831185 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature