Trypanosome bloodstream-specific flagellum attachment proteins can mediate attachment in an insect surface coat environment.

ABSTRACT: Throughout the life cycle of the unicellular parasite Trypanosoma brucei, its single flagellum remains laterally attached to the cell body by FLA and FLABP proteins, even as the parasite differentiates from the bloodstream form (BSF), found in the mammalian host, to the procyclic form (PCF), in the insect midgut. This differentiation is accompanied by changes in the dominant surface coat protein, from the variable surface glycoprotein to procyclins. There are stage-specific variants of the FLA and FLABP proteins, with FLA2 and FLA2BP found in BSFs, and FLA1 and FLA1BP in PCFs. Yet, how these proteins maintain flagellum attachment during the differentiation from BSFs to PCFs and the accompanying change in surface coat environment is unknown. Here, we used a double-induction system to test w

SUBMITTER: de Liz LV 

PROVIDER: S-EPMC12831198 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature