Sarcopenia defined by serum creatinine and cystatin C predicts poor survival outcomes in patients with cancers.

ABSTRACT:

Background

The prognostic significance of sarcopenia estimated by serum creatinine and cystatin C in cancer patients remained inconsistent. The purpose of the meta-analysis was to comprehensively evaluate the association between creatinine/cystatin C ratio(CCR) or sarcopenia index(SI) and survival outcomes in cancer patients with sarcopenia.

Methods

A comprehensive search of relevant studies was implemented by scrutinizing Pubmed, Web of science and Embase databases until June 30, 2024. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to evaluate the survival outcomes.

Results

18 studies from 17 articles involving 9908 patients were enrolled in the study. The meta-analysis indicated that low CCR was significantly associated with poor overal

SUBMITTER: Liu R 

PROVIDER: S-EPMC12831326 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature