Porphyromonas gingivalis extracellular vesicles promotes tumor metastasis in esophageal squamous cell carcinoma by inducing PRKACB/JNK/ NFATC2 axis.

ABSTRACT: Porphyromonas gingivalis (Pg), a common oral microorganism linked to periodontal disease, has been recently shown to play a significant role in oral and systemic health through the secretion of extracellular vesicles (EVs). Nevertheless, the implications of Porphyromonas gingivalis-derived extracellular vesicles (Pg-EVs) on esophageal squamous cell carcinoma (ESCC) metastasis and the corresponding underlying mechanisms continue to be shrouded in ambiguity. Our study aimed to determine whether and how Pg-EVs mediate ESCC metastasis. Using 16sRNA gene sequencing, FISH and bioinformatics we found that Pg was abundant in human ESCC cancerous tissues and was associated with poor prognosis in ESCC patients. Our results further revealed that Pg-EVs enhanced the migration and invasion of cancer ce

SUBMITTER: Hong K 

PROVIDER: S-EPMC12831332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature