Organophosphate ester exposure in pregnancy, gestational weight gain, and postpartum body composition in a U.S.-based longitudinal pregnancy cohort.

ABSTRACT:

Background

Organophosphate esters (OPEs) are replacement flame retardants that have been implicated as metabolic disruptors and linked to birth size across a number of epidemiologic studies. Little is known about how OPEs impact maternal weight and body composition from pregnancy through the postpartum period.

Methods

We measured OPE metabolites in mid-pregnancy urine samples from participants in a pregnancy cohort study based in Rochester, NY, USA. We calculated total gestational weight gain (GWG) based on clinical records (n = 278) and additionally measured weight retention and body fat percentage through bioelectric impedance at 6 (n = 205) and 12 months postpartum (n = 167). We fitted adjusted linear and logistic regression models examining OPE concentrations in relation

SUBMITTER: Barrett ES 

PROVIDER: S-EPMC12831425 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature