Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes.

ABSTRACT:

Background

Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of colorectal cancers.

Methods

In tumor and paired normal samples from 6,111 colorectal patients, we sequenced 199 genes identified from whole exome sequencing of over 1,100 tumors. Analyses focused on non-silent mutations. We classified significantly mutated genes after stratification by hypermutation status, and estimated associations of mutated genes/pathways with disease-specific (DS)-survival using Cox regression, adjusting for age, sex, mutation burden, hypermutation status, and study while accounting for multiple compari

SUBMITTER: Harrison TA 

PROVIDER: S-EPMC12831426 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature