Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profiling.

ABSTRACT:

Background

Gastrointestinal stromal tumors (GISTs) exhibit significant heterogeneity, posing substantial challenges for personalized treatment strategies. Patients often display varied responses to different therapeutic agents and dosages. Currently, the absence of robust and physiologically relevant in vitro models for GISTs impedes accurate prediction of therapeutic efficacy, thereby constraining the advancement of effective treatment strategies. Traditional 2D cell cultures fail to replicate the tumor microenvironment (TME) and lack patient-specific characteristics, limiting their predictive value. In contrast, three-dimensional bioprinting (3DP) technology faithfully recapitulates key histological architecture and molecular features of their parental tumors, enhancing the physi

SUBMITTER: Du L 

PROVIDER: S-EPMC12831436 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature