Genomic characterization and evolutionary analysis of Chikungunya virus strains in Guangzhou, China, 2025.

ABSTRACT:

Background

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has caused multiple widespread outbreaks and poses a significant public health threat. Recently, CHIKV outbreaks were reported in Guangdong Province, China. However, genomic data and information on local transmission remain limited.

Methods

We collected 19 CHIKV-positive samples from Guangzhou and carried out whole-genome sequencing via the Oxford Nanopore platform. The obtained sequences were subjected to mutational and phylogenetic analysis. Furthermore, amino acid substitutions during transmission were analyzed via DynaMut2 to assess their potential effects on protein stability.

Results

Phylogenetic analysis revealed that all 19 isolates belonged to the East/Central/South African (ECSA) lineag

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12831437 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature