The impact of sputum quality on Xpert positivity in active case-finding for TB.

ABSTRACT: BACKGROUND: Studies evaluating sputum quality and Xpert^® MTB/RIF positivity in the context of active case finding are scarce. We aimed to determine whether sputum quality is associated with Xpert positivity and whether the association differed according to demographic and clinical characteristics.METHODS: A cross-sectional analysis using data from a mass screening programme in Brazilian prisons was conducted from 2017 to 2021. We administered a standardised questionnaire, obtained a chest X-ray and collected a spot sputum sample for Xpert testing. Sputum quality was classified as 'salivary', 'mucoid/mucopurulent' or 'blood-stained'. We used log binomial regressions to estimate the relationship between sputum quality and Xpert positivity, assessing interactions with

SUBMITTER: Oliveira da Silva B 

PROVIDER: S-EPMC12831509 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature