Predicting loss of hepatitis B surface antigen and evaluating the durability of functional cure induced by pegylated interferon alpha: insights from a real-world study.

ABSTRACT:

Background

This study aims to identify the key factors influencing the loss of hepatitis B surface antigen (HBsAg) and durability of functional cure. Understanding these factors is crucial for identifying patient groups that may benefit from a pegylated interferon alpha (Peg-IFN-α) induced "functional cure" for hepatitis B, as well as for optimizing strategies to achieve and sustain HBsAg loss.

Methods

The study utilized real-world data, including 378 patients with chronic hepatitis B virus (HBV) infection who received treatment with Peg-IFN-αfor 24 weeks or longer. Patients were grouped based on their response at 24 and 48 weeks of treatment, and predictive factors for the response were calculated through regression analysis. Additionally, 195 subjects who achieved HBsAg lo

SUBMITTER: Xu X 

PROVIDER: S-EPMC12831512 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature