Mortality Benefit of Tranexamic Acid for Hemorrhage With Concurrent Traumatic Brain Injury: Outcomes From a Prospective Cohort Study in a High-Trauma, Prolonged Care Setting.

ABSTRACT:

Background

Traumatic brain injury (TBI) and hemorrhage are leading causes of trauma death and disability worldwide. The concurrence of hemorrhage and brain injury carries a two-fold increase in mortality and clinical management of patients with concurrent TBI and hemorrhage is challenging. Tranexamic acid (TXA) has been shown to reduce mortality from hemorrhage and TBI independently, however there is sparse evidence on the potential benefit of TXA in patients with both non-head hemorrhage and TBI.

Methods

We conducted a secondary database analysis of EpiC, a multicenter, prospective cohort of trauma patients in South Africa. We compared the morbidity and mortality of patients experiencing both non-head hemorrhage and TBI who received TXA within 3-h post-injury versus similar

SUBMITTER: Dixon JM 

PROVIDER: S-EPMC12831529 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature