Associations between prenatal metal mixtures and allergic symptoms in childhood.

ABSTRACT: Previous work has linked exposure to individual metals in pregnancy to allergic outcomes postnatally but few studies have examined metals exposure as a mixture. Analysis included 542 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) birth cohort in Mexico City. Levels of arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), manganese (Mn), nickel (Ni) and lead (Pb) were analyzed in blood collected during the 2^nd and 3^rd trimesters. Atopic dermatitis and allergic rhinitis symptoms were assessed via questionnaire at 4-6 years and 6-8 years of age. Mixture associations were modeled using repeated holdout WQS regression with adjustment for relevant covariates. We found evidence of a 2^nd trime

SUBMITTER: Pandey A 

PROVIDER: S-EPMC12831541 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature