Plasma Inflammatory Biomarkers Lack Strong Association With Cognitive Outcomes Among Young Adults With Perinatal HIV Exposure and/or Acquisition.

ABSTRACT:

Background

Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or without prior HIV disease progression.

Setting

We analyzed participants with plasma samples and NIH Toolbox cognitive scores at entry into a multisite longitudinal cohort in the United States.

Methods

Participants were subdivided into groups by HIV status: YAPHIV who experienced a stage 3 event (YAPHIV-W3, indicating history of HIV disease progression), YAPHIV who had not (YAPHIV-WO3), and YAPHEU. Fifteen biomarkers were measured. Principal component analysis was used to derive biomarker principal component (PC) scores, with 4 PCs re

SUBMITTER: McHenry MS 

PROVIDER: S-EPMC12831584 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature