Genome-wide association mapping in Arabidopsis identifies previously known flowering time and pathogen resistance genes.

ABSTRACT: There is currently tremendous interest in the possibility of using genome-wide association mapping to identify genes responsible for natural variation, particularly for human disease susceptibility. The model plant Arabidopsis thaliana is in many ways an ideal candidate for such studies, because it is a highly selfing hermaphrodite. As a result, the species largely exists as a collection of naturally occurring inbred lines, or accessions, which can be genotyped once and phenotyped repeatedly. Furthermore, linkage disequilibrium in such a species will be much more extensive than in a comparable outcrossing species. We tested the feasibility of genome-wide association mapping in A. thaliana by searching for associations with flowering time and pathogen resistance in a sample of 95 accessions

SUBMITTER: Aranzana MJ 

PROVIDER: S-EPMC1283159 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature