Global population structure of Shiga toxin-producing <i>Escherichia coli</i> O103:H2 and the variation in their major virulence factor-encoding genetic elements.

ABSTRACT: Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of serious gastrointestinal illness, including diarrhoea, haemorrhagic colitis and life-threatening haemolytic-uraemic syndrome. Although O157:H7 STEC strains are the most prevalent, the incidence of STEC infections caused by several other serotypes has recently increased. O103:H2 STEC is one of these major non-O157 STEC strains, but systematic whole-genome sequence (WGS) analyses have not yet been conducted. To gain a global phylogenetic overview of O103:H2 STEC based on WGSs, we analysed 2,701 WGSs of O103:H2 strains, including 193 sequenced in this study. Sequence type (ST)-based classification divided the O103:H2 strains into three distinct E. coli lineages. As the virulence marker genes of typical STECs

SUBMITTER: Taniguchi I 

PROVIDER: S-EPMC12831630 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature