CD71⁺ Red Blood Cells Mediate Increased Erythrophagocytosis and Reduce Monocyte Number in a Monocyte Suspension Assay.

ABSTRACT: Adverse reactions from donor-recipient sex-mismatched transfusions have been reported in the field of transfusion medicine. Immature CD71⁺ red blood cells (CD71⁺ RBCs) may influence these reactions through an immunomodulatory mechanism potentially linked to enriched intracellular reactive oxygen species (ROS). This study was conducted to investigate the effect of CD71⁺ RBCs on erythrophagocytosis, a common in vitro test for hemolysis risk in incompatible blood transfusions. Enriched CD71⁺ RBCs and CD71^- RBCs were exposed to allogenic peripheral blood mononuclear cells (PBMCs). CD71⁺ RBCs were also incubated with anti-D sensitised CD71^- RBCs and PBMCs, in varying ratios, to assess any dose-dependent behaviour. An R

SUBMITTER: Li W 

PROVIDER: S-EPMC12831645 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature