Astrocyte-vascular interplay in Alzheimer's disease pathology: Novel insights into stage-specific biomarkers and therapeutic targets.

ABSTRACT:

Introduction

We examined how neurovascular and astrocytic response alter cognition in Alzheimer's disease (AD).

Methods

Cognitive scores, biomarkers of AD and astrocytic activation, vascular factors, and brain structure data from 693 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed using analysis of covariance (ANCOVA), multiple linear and cox regression, mediation and mixed models.

Results

Cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGF)-C levels varied significantly across cognitive stages (normal cognition [CN], mild cognitive impairment [MCI], and AD). Vascular factors showed stage-specific patterns with amyloid beta (Aβ) and tau pathology. Higher CSF VEGF-C and angiotensin-converting enzyme (ACE) correlated with bet

SUBMITTER: Sheng Z 

PROVIDER: S-EPMC12831801 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature