Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?

ABSTRACT:

Objectives

To investigate the association between the MTHFR 677C-->T polymorphism and coronary heart disease, assessing small study bias and heterogeneity between studies.

Data sources

Medline and Embase citation searches between January 2001 and August 2004; no language restrictions.

Study selection

Case-control and prospective studies of association between MTHFR 677C-->T variant and myocardial infarction, coronary artery occlusion, or both; 80 studies were included.

Data extraction

Data on genotype frequency and mean homocysteine concentrations by genotype were extracted. Odds ratios were calculated for TT genotype versus CC genotype. Heterogeneity was explored, with stratification by geographical region of the study samples, and meta-regression by differenc

SUBMITTER: Lewis SJ 

PROVIDER: S-EPMC1283183 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature