Is Cooler Safer and More Advantageous? A Feasibility Study in Rabbits.

ABSTRACT:

Objectives

This study hypothesizes that induced hypothermia (IH) can safely extend aortic cross-clamp (ACC) time, significantly reducing metabolic burden and end-organ injury, thereby enabling more comprehensive aortic arch reconstructions and offering distinct advantages.

Methods

In this experimental animal research, 62 New Zealand white rabbits were randomized into normothermia (39°C) and mild hypothermia (35°C) groups. Animals in each group underwent proximal aortic arch (PAA) clamping for 20, 30, or 40 minutes. Serial blood samples measured biochemistry, oxidative stress biomarkers, arterial and mixed venous blood gases, and lactate levels. Kidney and liver tissues were harvested for histopathological evaluation of ischaemic changes.

Results

Normothermic rabbits e

SUBMITTER: Sisli E 

PROVIDER: S-EPMC12831934 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature