Identifying Optimal Thresholds for Early Opioid Use Frequency in Predicting Buprenorphine Outcomes.

ABSTRACT: Objective: Early prognostic indicators of nonresponse to buprenorphine treatment for opioid use disorder can inform targeted efforts to improve outcomes. Opioid use in the first 2-3 weeks of treatment predicts later outcomes, yet it is unclear what frequency of opioid use confers risk. We aimed to (1) identify thresholds for the frequency of early opioid use that optimally predict later sustained use and (2) quantify associations between thresholds and continuous treatment outcomes.Method: We used data from 2 clinical trials of buprenorphine (N=562; mean age=34 years; 38% female), which were conducted from 2006-2009 and 2007-2011. Area under the receiver operating characteristic curve analyses identified optimal thresholds for opioid frequency during the first 4 weeks in pred

SUBMITTER: Votaw VR 

PROVIDER: S-EPMC12832008 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature