Craniofacial and whole-skeleton fracture patterns in osteogenesis imperfecta: Findings from a nationwide U.S. insurance claims database.

ABSTRACT:

Background

Osteogenesis imperfecta (OI) is an inherited connective tissue disease characterized by lifelong skeletal fragility and recurrent fractures. While most prior research has focused on long bone fractures in selected clinical cohorts, population-based estimates of craniofacial and site-specific fracture risk in OI remain largely limited. This study used insurance claims data to quantify the period prevalence, anatomical distribution, and predictors of fractures in individuals with versus without OI.

Methods

A retrospective cohort study was conducted using the IBM® MarketScan® Multi-State Medicaid (2016-2022, all ages) and Commercial Databases (2016-2022, < 65 years old). Diagnosis of OI and all fractures were identified using ICD and CPT codes recorded during healthc

SUBMITTER: Sung HH 

PROVIDER: S-EPMC12832009 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature