GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis.

ABSTRACT: Next-generation sequencing (NGS) has revolutionized genome biology by enabling rapid whole-genome sequencing (WGS) and driving its adoption in research and clinical settings. However, the high-throughput nature of NGS and the complexity of downstream analyses demand robust computational solutions. We present GeNePi, a modular bioinformatic pipeline for efficient and accurate analysis of WGS short paired-end reads. GeNePi is a genomics analysis pipeline built on the Nextflow framework, integrating graphics processing unit (GPU)-accelerated algorithms from NVIDIA Clara Parabricks to enable high-performance variant discovery. The pipeline supports multiple workflow configurations and automates the detection of a broad range of genomic variants, including single-nucleotide variants and small i

SUBMITTER: Marangoni S 

PROVIDER: S-EPMC12832024 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature