Drinking water nitrate, disinfection byproducts, and prostate cancer incidence in the Agricultural Health Study.

ABSTRACT:

Background

Drinking water can be an important source of exposure to nitrate and disinfection by-products, including trihalomethanes (THMs) and haloacetic acids (HAAs). N-nitroso compounds formed endogenously after nitrate ingestion are animal carcinogens, and THM and HAA exposures increase the risk of some cancers. Our objectives were to evaluate associations of drinking water nitrate and disinfection byproducts with total and aggressive (distant stage, poorly differentiated grade, fatal, or Gleason score ≥7) prostate cancer in the Agricultural Health Study cohort.

Methods

Male participants who were cancer free and used private wells or public water supplies (PWS) for drinking water at enrollment (1993-1997, n = 40 403) were followed through 2021 (mean = 21.9 years). Average

SUBMITTER: Spaur M 

PROVIDER: S-EPMC12832043 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature