Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.

ABSTRACT: Monoamine neurotransmitters such as dopamine and serotonin control important brain pathways, including movement, sleep, reward and mood¹. Dysfunction of monoaminergic circuits has been implicated in various neurodegenerative and neuropsychiatric disorders². Vesicular monoamine transporters (VMATs) pack monoamines into vesicles for synaptic release and are essential to neurotransmission^3-5. VMATs are also therapeutic drug targets for a number of different conditions^6-9. Despite the importance of these transporters, the mechanisms of substrate transport and drug inhibition of VMATs have remained elusive. Here we report cryo-electron microscopy structures of the human vesicular monoamine transporter VMAT2 in complex with the antichorea drug tetraben

SUBMITTER: Pidathala S 

PROVIDER: S-EPMC12832108 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature