Roche Canada stops distributing oseltamivir.
Ontology highlight
ABSTRACT:
SUBMITTER: Spurgeon D
PROVIDER: S-EPMC1283217 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Publications
Roche Canada stops distributing oseltamivir.
BMJ (Clinical research ed.) 20051101 7524
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Project description: Not available
| S-EPMC1273441 | biostudies-literature
Project description:This study explores processing characteristics of a glottal stop in Maltese which occurs both as a phoneme and as an epenthetic stop for vowel-initial words. Experiment 1 shows that its hyperarticulation is not necessarily mapped onto an underlying form, although listeners may interpret it as underlying at a later processing stage. Experiment 2 shows that listeners' experience with a particular speaker's use of a glottal stop exclusively as a phoneme does not modulate competition patterns accordingly. Not only are vowel-initial words activated by [ʔ]-initial forms, but /ʔ/-initial words are also activated by vowel-initial forms, suggesting that lexical access is not constrained by an initial acoustic mismatch that involves a glottal stop. Experiment 3 reveals that the observed pattern is not generalizable to an oral stop /t/. We propose that glottal stops have a special status in lexical processing: it is prosodic in nature to be licensed by the prosodic structure.
| S-EPMC8604299 | biostudies-literature
Project description:Pandemic influenza is an international public health concern. In light of the persistent threat of H5N1 avian influenza and the recent pandemic of A/H1N1swine influenza outbreak, public health agencies around the globe are continuously revising their preparedness plans. The A/H1N1 pandemic of 2009 demonstrated that influenza activity and severity might vary considerably among age groups and locations, and the distribution of an effective influenza vaccine may be significantly delayed and staggered. Thus, pandemic influenza vaccine distribution policies should be tailored to the demographic and spatial structures of communities. Here, we introduce a bi-criteria decision-making framework for vaccine distribution policies that is based on a geospatial and demographically-structured model of pandemic influenza transmission within and between counties of Arizona in the Unites States. Based on data from the 2009-2010 H1N1 pandemic, the policy predicted to reduce overall attack rate most effectively is prioritizing counties expected to experience the latest epidemic waves (a policy that may be politically untenable). However, when we consider reductions in both the attack rate and the waiting period for those seeking vaccines, the widely adopted pro rata policy (distributing according to population size) is also predicted to be an effective strategy.
| S-EPMC4295509 | biostudies-literature
Project description:Imagine being in a crowded room with a cacophony of speakers and having the ability to focus on or remove speech from a specific 2D region. This would require understanding and manipulating an acoustic scene, isolating each speaker, and associating a 2D spatial context with each constituent speech. However, separating speech from a large number of concurrent speakers in a room into individual streams and identifying their precise 2D locations is challenging, even for the human brain. Here, we present the first acoustic swarm that demonstrates cooperative navigation with centimeter-resolution using sound, eliminating the need for cameras or external infrastructure. Our acoustic swarm forms a self-distributing wireless microphone array, which, along with our attention-based neural network framework, lets us separate and localize concurrent human speakers in the 2D space, enabling speech zones. Our evaluations showed that the acoustic swarm could localize and separate 3-5 concurrent speech sources in real-world unseen reverberant environments with median and 90-percentile 2D errors of 15 cm and 50 cm, respectively. Our system enables applications like mute zones (parts of the room where sounds are muted), active zones (regions where sounds are captured), multi-conversation separation and location-aware interaction.
| S-EPMC10514314 | biostudies-literature
Project description:BackgroundCancer is a disease of genome alterations that arise through the acquisition of multiple somatic DNA sequence mutations. Some of these mutations can be critical for the development of a tumor and can be useful to characterize tumor types or predict outcome.DescriptionWe have constructed an integrated biological information system termed the Roche Cancer Genome Database (RCGDB) combining different human mutation databases already publicly available. This data is further extended by hand-curated information from publications.The current version of the RCGDB provides a user-friendly graphical interface that gives access to the data in different ways: (1) Single interactive search by genes, samples, cell lines, diseases, as well as pathways, (2) batch searches for genes and cell lines, (3) customized searches for regularly occurring requests, and (4) an advanced query interface enabling the user to query for samples and mutations by various filter criteria.ConclusionThe interfaces of the presented database enable the user to search and view mutations in an intuitive and straight-forward manner. The database is freely accessible at http://rcgdb.bioinf.uni-sb.de/MutomeWeb/.
| S-EPMC3114700 | biostudies-literature
Project description:Earthquakes caused by human activities receive scrutiny due to the risks and hazards they pose. Seismicity that occurs after the causative anthropogenic operation stops has been particularly problematic-both because of high-profile cases of damage caused by this trailing seismicity and due to the loss of control for risk management. With this motivation, we undertake a statistical examination of how induced seismicity stops. We borrow the concept of Båth's law from tectonic aftershock sequences. Båth's law anticipates the difference between magnitudes in two subsets of seismicity as dependent on their population count ratio. We test this concept for its applicability to induced seismicity, including ~ 80 cases of earthquakes caused by hydraulic fracturing, enhanced geothermal systems, and other fluid-injections with clear operational end points. We find that induced seismicity obeys Båth's law: both in terms of the magnitude-count-ratio relationship and the power law distribution of residuals. Furthermore, the distribution of count ratios is skewed and heavy-tailed, with most earthquakes occurring during stimulation/injection. We discuss potential models to improve the characterization of these count ratios and propose a Seismogenic Fault Injection Test to measure their parameters in situ. We conclude that Båth's law quantifies the occurrence of earthquake magnitudes trailing anthropogenic operations.
| S-EPMC8786864 | biostudies-literature
Project description:ObjectivesAmid growing calls for police reform, it is imperative to reassess whether police actions designed to improve public safety are associated with injury prevention. This study aims to examine the relationship between the police traffic stops (PTSs) and motor vehicle crash (MVC) deaths at the state level. We hypothesize that increased PTSs would be associated with reduced MVC deaths.MethodsWe retrospectively analyzed PTSs and MVC deaths at the state level from 2004 to 2016. Police traffic stops data were from 33 state patrols from the Stanford Open Policing Project. The MVC deaths data were collected from the National Highway Traffic Safety Administration. The vehicle miles traveled data were from the Federal Highway Administration Office of Highway Policy Information. All data were adjusted per 100 million vehicle miles traveled (100MVMT) and were analyzed as state-level time series cross-sectional data. The dependent variable was MVC deaths per 100MVMT, and the independent variable was number of PTSs per 100MVMT. We performed panel data analysis accounting for random and fixed state effects and changes over time.ResultsThirty-three state patrols with 235 combined years were analyzed, with a total of 161,153,248 PTSs. The PTS rate varied by state and year. Nebraska had the highest PTS rate (3,637/100MVMT in 2004), while Arizona had the lowest (0.17/100MVMT in 2009). Motor vehicle crash deaths varied by state and year, with the highest death rate occurring in South Carolina in 2005 (2.2/100MVMT) and the lowest in Rhode Island in 2015 (0.57/100MVMT). After accounting for year and state-level variability, no association was found between PTS and the MVC death rates.ConclusionState patrol traffic stops are not associated with reduced MVC deaths. Strategies to reduce death from MVC should consider alternative strategies, such as motor vehicle modifications, community-based safety initiatives, improved access to health care, or prioritizing trauma system.Level of evidenceRetrospective epidemiological study, level IV.
| S-EPMC8900371 | biostudies-literature
Project description:AimsThe aims of the present study were to compare the pharmacokinetics of oseltamivir and its active antiviral metabolite oseltamivir carboxylate in obese and non-obese individuals and to determine the effect of obesity on the pharmacokinetic properties of oseltamivir and oseltamivir carboxylate.MethodsThe population pharmacokinetic properties of oseltamivir and oseltamivir carboxylate were evaluated in 12 obese [body mass index (BMI) ≥30 kg m(-2) ) and 12 non-obese (BMI <30 kg m(-2) ) Thai adult volunteers receiving a standard dose of 75 mg and a double dose of 150 mg in a randomized sequence. Concentration-time data were collected and analysed using nonlinear mixed-effects modelling.ResultsThe pharmacokinetics of oseltamivir and oseltamivir carboxylate were described simultaneously by first-order absorption, with a one-compartment disposition model for oseltamivir, followed by a metabolism compartment and a one-compartment disposition model for oseltamivir carboxylate. Creatinine clearance was a significant predictor of oseltamivir carboxylate clearance {3.84% increase for each 10 ml min(-1) increase in creatinine clearance [95% confidence interval (CI) 0.178%, 8.02%]}. Obese individuals had an approximately 25% (95% CI 24%, 28%) higher oseltamivir clearance, 20% higher oseltamivir volume of distribution (95% CI 19%, 23%) and 10% higher oseltamivir carboxylate clearance (95% CI 9%, 11%) compared with non-obese individuals. However, these altered pharmacokinetic properties were small and did not change the overall exposure to oseltamivir carboxylate.ConclusionsThe results confirmed that a dose adjustment for oseltamivir in obese individuals is not necessary on the basis of its pharmacokinetics.
| S-EPMC4876175 | biostudies-literature
Project description:This study assessed the relative clinical sensitivity and specificity, as well as reproducibility, for high-risk HPV types of the Roche cobas HPV test when processed using the Roche cobas 5800 system. The results from this study demonstrate that the cobas HPV test using the cobas 5800 system fulfils the Meijer criteria for use in population-based cervical screening. This clinical validation study also examines the clinical sensitivity and specificity based on partial genotyping, with separate detection of HPV16 and HPV18, compared with the Roche cobas 4800 HPV test, a second-generation standard comparator assay. The cobas HPV test has a relative clinical sensitivity of 1.000, when compared with the cobas 4800 HPV test to detect histologically confirmed CIN2+ lesions in woman aged 30 years or older, with a relative clinical specificity of 0.995. The general intra- and inter-laboratory agreement for the cobas HPV test on the cobas 5800 system for finding a HPV positive result were 99.1% and 99.6%, respectively.IMPORTANCEThis study demonstrates, for the first time, the clinical performance of the Roche cobas HPV test when processed using the new cobas 5800 system [cobas (5800)]. This study shows that the cobas (5800) demonstrates relative clinical sensitivity and specificity, when compared with a standard comparator HPV test, which meets the international HPV test validation requirements. Intra- and inter-laboratory reproducibility also fulfills these criteria. The current study demonstrates that the cobas (5800) can be used for primary HPV-based cervical screening on cervical specimens.
| S-EPMC11448194 | biostudies-literature
Project description:The purpose of the present study is to investigate mental well-being among youth after witnessing police stops. A national, urban-born sample of youth in the USA from the most recent wave (2014-2017) of the Fragile Families and Child Wellbeing Study (FFCWS) was employed, with a focus on youth who had not been directly stopped by police (N = 2506). We used t-tests and multivariable ordinary least squares (OLS) regression to estimate direct associations, product-term analysis to test for effect modification by gender and race/ethnicity, and the Karlson-Holm-Breen (KHB) method to assess for mediation by experiences of emotional distress during a stop. Findings indicate that youth who have witnessed police stops report significantly higher levels of depression (t = 5.93, p < 0.01) and anxiety (t = 6.57, p < 0.01) and lower levels of happiness (t = - 4.02, p < 0.01) following the stop than those who have not. Among youth witnessing stops (N = 1488), more intrusive witnessed encounters correspond to diminished mental well-being across indicators, in part due to elevated emotional distress during witnessed stops. Findings hold regardless of gender, yet vary somewhat by race and ethnicity, with youth of color reporting less anxiety than their White counterparts after witnessing an intrusive stop, but reporting greater reductions in happiness. Collectively, our findings suggest that witnessing police stops may contribute to inequities in youth mental well-being. A public health approach that combines prevention and treatment strategies may mitigate the harms of police exposure and reduce disparities in youth well-being.
| S-EPMC9561497 | biostudies-literature