Enabling global access to potent subunit vaccines with a simple and scalable injectable hydrogel platform.

ABSTRACT: Vaccines have been crucial to dramatic improvements in global health in recent decades, yet next-generation vaccine technologies remain out of reach for much of the world. In particular, there are two overarching global needs: (i) develop vaccines eliciting more potent and durable immune responses, especially to reduce incidence of highly communicable diseases, and (ii) enable simple and cost-efficient formulation to maximize global access. Here, we develop an injectable hydrogel depot technology prepared through physical mixing of commercially available, generally recognized as safe (GRAS) polymers that can be formulated with subunit vaccine components to improve immune responses compared to standard vaccine formulations. We demonstrate that these hydrogels are shear-thinning and rapidly

SUBMITTER: Ganesh P 

PROVIDER: S-EPMC12832181 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature