Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis.

ABSTRACT: The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnologies for therapy and diagnosis. However, integrating artificial photoredox catalysis into living systems presents significant challenges, primarily due to concerns over low targetability, low compatibility with complex biological environments, and the safety risks associated with photocatalyst toxicity. To address these challenges, herein, we present a novel bioorthogonally activatable photoredox catalysis approach. In this approach, potent photocatalyst selection via atom replacement of the rhodamine core yielded the bioorthogonally activatable photocatalyst (PC-Tz). The introduction of 1,

SUBMITTER: Kim J 

PROVIDER: S-EPMC12832188 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature