ADIPOQ polymorphisms and haplotypes affect circulating adiponectin levels and their association with gestational hypertension and preeclampsia.

ABSTRACT:

Introduction

Imbalance of adipocytokines has been implicated in endothelial dysfunction in hypertensive disorders of pregnancy (HDP). Adiponectin is an adipocytokine that regulates metabolism, insulin sensitivity, and inflammation, and increased adiponectin levels have been associated with mortality in subjects with cardiovascular diseases. Adiponectin also plays a role in trophoblast invasion during placental development. ADIPOQ gene has polymorphisms that modulate adiponectin levels and are linked to several diseases, including gestational hypertension (GH) and preeclampsia (PE). However, no previous study has examined whether ADIPOQ SNPs and haplotypes affect adiponectin levels in HDP.

Objectives

We assessed and compared plasma adiponectin levels among healt

SUBMITTER: Froes de Castro RN 

PROVIDER: S-EPMC12832239 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature