Determining optimal clinical target volume margins based on microscopic tumor extension in patients with non-small-cell lung cancer undergoing chemotherapy or chemotherapy combined with immunotherapy.

ABSTRACT:

Background

There is currently no unified understanding of the clinical target volume (CTV) margins for radiotherapy in non-small cell lung cancer (NSCLC), after chemotherapy or chemotherapy combined with immunotherapy. This study aimed to explore margins around the gross tumor volume (GTV) to infer the CTV in NSCLC, after chemotherapy or chemotherapy combined with immunotherapy, using microscopic tumor extension (ME).

Methods

We retrospectively analyzed 185 patients with stage II and III NSCLC who underwent surgery without neoadjuvant therapy or with neoadjuvant chemotherapy or chemotherapy combined with immunotherapy. We assessed the correlation between the radiological (last preoperative computed tomography image) and pathological (postoperative gross specimens) tumor size

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12832255 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature