A novel functional water significantly modulates the gut microbiota and decreases the basal level of inflammation in mice.

ABSTRACT:

Background

Accumulating evidence has identified the gut microbiota as a critical regulator of biological processes such as immune homeostasis, and its dysbiosis has been implicated in the pathogenesis of numerous diseases. Current strategies for modulating the gut microbiota remain limited by several challenges: low colonization efficiency (probiotics), interindividual variability in host response (prebiotics), and safety concerns (antibiotics).

Methods

We investigated the effects of a physically processed, additive-free purified water (Koishio water, KW) on gut microbiota composition and basal inflammatory status in healthy mice.

Results

First, KW drinking significantly increased the diversity and richness of the gut microbiota of the mice, including increased abunda

SUBMITTER: Men Y 

PROVIDER: S-EPMC12832262 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature