Investigation of the pharmacological mechanisms of Denglao Qingguan decoction in inhibiting viral pneumonia through network pharmacology and in vitro laboratory validation.

ABSTRACT:

Introduction

Respiratory viral infection poses a serious threat to human health, underscoring the need for effective agents to prevent and treat these conditions.

Objective

This study aimed to investigate Denglao Qingguan decoction (DLQGD), a traditional formula used in the management of respiratory infections, and to elucidate its efficacy and mechanisms against viral pneumonia.

Methods

Network pharmacology was employed to investigate the potential mechanism of DLQGD against viral pneumonia. The components of DLQGD were analyzed by High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (HPLC-Q-TOF MS). The antiviral effects of DLQGD against respiratory syncytial virus (RSV), influenza virus and severe acute respiratory syndrome coronavirus

SUBMITTER: Lei B 

PROVIDER: S-EPMC12832263 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature