Efficacy and safety of antioxidants and dietary therapies for epilepsy: an umbrella meta-analysis.

ABSTRACT:

Background

Epilepsy is a prevalent chronic neurological disorder. A substantial proportion of patients develop drug-resistant epilepsy. Existing antiepileptic drugs are associated with adverse effects and demonstrate limited efficacy in refractory cases. Oxidative stress plays a critical role in the pathogenesis of epilepsy. Antioxidants such as vitamin D, vitamin E, and melatonin, as well as dietary therapies like the ketogenic diet, have garnered attention as potential adjunctive treatments. However, existing studies exhibit significant controversy and heterogeneity.

Objective

To evaluate the efficacy and safety of antioxidants and dietary therapies in the treatment of epilepsy, and to provide evidence-based support for clinical decision-making.

Methods

Systematic s

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12832287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature