Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis.

ABSTRACT:

Background

Opioid-induced constipation (OIC) is a common and serious side effect of long-term opioid analgesic therapy. As traditional laxatives often show limited efficacy, it is crucial to explore treatment strategies that effectively relieve constipation without compromising analgesic effects. In response to this clinical need, Opioid-receptor antagonists have been approved for OIC. Although new evidence has emerged in recent years, a comprehensive analysis of efficacy outcomes (such as constipation symptoms, quality of life, and satisfaction) is still lacking.

Objective

To summarise and analyze evidence on the efficacy and safety of opioid-receptor antagonists in treating patients with OIC.

Method

A systematic search of randomized controlled trials (RCTs) was cond

SUBMITTER: Li Y 

PROVIDER: S-EPMC12832312 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature