Development of a short-term prognostic model for hepatitis B-related acute-on-chronic liver failure in a dual-center cohort.

ABSTRACT:

Background and aims

Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome marked by rapid progression and high short-term mortality. In the Asia-Pacific region, where the hepatitis B virus (HBV) is endemic, HBV-related ACLF (HBV-ACLF) represents the most common subtype. The aim of this study was to develop and validate a concise and accurate nomogram for predicting 28-day mortality in patients with HBV-related ACLF.

Methods

A total of 159 patients with HBV-ACLF were enrolled, including 113 in the training cohort and 46 in the validation cohort. Clinical characteristics, routine laboratory parameters, and inflammatory cytokine levels were collected. In the training cohort, least absolute shrinkage and selection operator (LASSO) regression was applied to select v

SUBMITTER: Deng H 

PROVIDER: S-EPMC12832347 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature