Association between HALP score and in-hospital mortality in sepsis patients: a multicenter retrospective cohort study with external validation.

ABSTRACT:

Background

The HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) score integrates key parameters reflecting nutritional and immune status. However, its prognostic value for in-hospital mortality in sepsis patients remains underexplored.

Objective

To investigate the association between HALP score and in-hospital mortality in sepsis patients using two large critical care databases.

Methods

We conducted a retrospective cohort study including adult patients with Sepsis-3 from the eICU Collaborative Research Database (derivation cohort, n = 12,899) and the MIMIC-IV database (validation cohort, n = 3,726). HALP was calculated as (hemoglobin × albumin × lymphocyte count)/platelet count, using first available values upon ICU admission. Restricted cubic spline

SUBMITTER: Lv X 

PROVIDER: S-EPMC12832424 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature