Modified EASIX score on day 7 predicts survival and non-relapse mortality in pediatric acute leukemia undergoing haploidentical stem cell transplantation.

ABSTRACT:

Background

The Endothelial Activation and Stress Index (EASIX) has been validated in adult hematopoietic stem cell transplantation (HSCT) recipients as a predictor of overall survival (OS), non-relapse mortality (NRM), and endothelial-related complications. However, the prognostic significance in children receiving haploidentical donor (HID) transplantation based on myeloablative conditioning (MAC) is still uncertain.

Method

Pediatric leukemia patients who underwent HID transplantation at the Children's Hospital of Soochow University between January 2020 and December 2024 were retrospectively reviewed. Based on transplantation dates, patients were assigned to training and validation cohorts. EASIX (lactate dehydrogenase (U/L) × creatinine (mg/dL)/platelet (10⁹ cel

SUBMITTER: Cui K 

PROVIDER: S-EPMC12832470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature