Multiple sclerosis and the risk of dementia: a real-world, nationwide cohort study.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that often causes cognitive impairment. This study aimed to investigate the association between MS and the risk of dementia in a large, nationwide Taiwanese cohort and to examine the potential impact of Disease-modifying drugs (DMDs) on the dementia incidences.

Methods

We conducted a population-based cohort study using Taiwan's National Health Insurance Research Database (NHIRD) between 2000 and 2015. Adults aged ≥20 years with a diagnosis of MS (n = 10,525) were matched 1:3 by age, sex, index date, and healthcare utilization to non-MS controls (n = 31,575). Dementia diagnoses were confirmed ≥1 year after the MS diagnosis. The Fine and Gray competing risks model was applied

SUBMITTER: Chen TA 

PROVIDER: S-EPMC12832492 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature