Mandatory food fortification in the eastern Mediterranean region results in reduced prevalence of neural tube defects.

ABSTRACT:

Introduction

Neural Tube Defects (NTDs) are preventable congenital malformations affecting the brain and spinal cord that occur very early in pregnancy, often before gestation is recognized. Globally, at least 20 per 10,000 live births are estimated to be affected by NTDs, although the true prevalence is likely higher due to unreported miscarriages, elective terminations, and gaps in surveillance systems. Mandatory fortification of staple foods with folic acid (Vitamin B9) is widely recognized as the most effective and cost-efficient strategy to reduce the prevalence of NTDs, whereas voluntary dietary supplementation programs have demonstrated limited uptake and population-level impact.

Methods

This study employs a situational analysis of mandatory food fortification policie

SUBMITTER: Roozen S 

PROVIDER: S-EPMC12832505 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature