Bone Morphogenetic Protein 6 Attenuates Psoriasis Pathogenesis by Suppressing Th17 Cell Differentiation.

ABSTRACT: Bone morphogenetic protein (BMP) signaling has multiple functions in immune cells, especially in the differentiation of T cells. Previously, we found that BMP6 can dramatically promote the IFN-γ production in Th1. However, the interactions between BMP6 and Th17 cells remain poorly characterized. The evidence implicates dysregulated Th17 cell differentiation as a pivotal mechanism in psoriatic pathogenesis, yet the therapeutic potential of BMP6 in this autoimmune disease needs to be further explored. This study aimed to evaluate the potentially beneficial role of BMP6 in the Th17-induced psoriatic models and investigate its possible mechanisms. Th17 cells were intervened with BMP6 in vitro. The differentiation of Th17 was observed through multi-platform assessment combining flow cytometry,

SUBMITTER: Fu J 

PROVIDER: S-EPMC12832584 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature