Sputum from Individuals with Primary Ciliary Dyskinesia Drives M2-like Macrophage Polarization.

ABSTRACT:

Introduction

Primary ciliary dyskinesia (PCD) is a rare, congenital condition in which impaired ciliary function leads to bronchiectasis and progressive lung function decline. Bronchiectasis development is believed to involve infection and inflammation but is incompletely understood. Macrophages play a central role in cellular immune response, contributing to both pathogen clearance and immunoregulation. Depending on local stimuli, macrophages are polarized towards pro-inflammatory (M1) or pro-resolution/phagocytic (M2) phenotypes. This study aims to investigate the effects of PCD sputum on macrophage polarization.

Methods

Sputum from 27 individuals with PCD and seven healthy controls were used to stimulate healthy monocyte-derived macrophages. Macrophage polarization was de

SUBMITTER: Wahlander J 

PROVIDER: S-EPMC12832589 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature