CGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activation of the TREM2-DAP10-PI3K Pathway.

ABSTRACT: Ischemic stroke (IS), a multifaceted neurodegenerative disorder characterized by neuroinflammation and neuronal damage, is critically linked to the cGAS-STING pathway, a key mediator of neuroinflammatory responses during cerebral ischemia. However, the specific role of the STING agonist 2',3'-cGAMP (cGAMP) in modulating ischemic brain injury remains poorly understood. In this study, we investigated the therapeutic effects of cGAMP in a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R) and in BV2 microglial cells subjected to oxygen-glucose deprivation/reperfusion (OGD/R). Network pharmacology analysis was further employed to predict potential molecular targets and mechanisms underlying cGAMP's action in IS. To validate these findings, TREM2-specific small interfering RNA (

SUBMITTER: Li X 

PROVIDER: S-EPMC12832594 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature