Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition.

ABSTRACT: Deoxyribonuclease I (DNase I) is an enzyme that hydrolyzes the phosphodiester bonds in the DNA backbone, enabling efficient DNA degradation. This activity is particularly relevant for degrading extracellular DNA (eDNA), a key structural component of the biofilm extracellular matrix that enhances bacterial attachment to implant surfaces and promotes cell-to-cell adhesion. By disrupting this matrix, DNase I offers significant potential to indirectly inhibit biofilm formation and reduce the risk of implant-associated infections (IAIs). In previous work, we developed a rapid electric field-assisted technique for producing anti-infective DNase I coatings on titanium (Ti) implant surfaces. To further evaluate clinical applicability, this study investigates the mechanical stability and in vitr

SUBMITTER: Aktan MK 

PROVIDER: S-EPMC12832641 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature