The lichen secondary metabolite lichesterinic acid exhibits antibiofilm activity against fungal pathogens.

ABSTRACT: Lichens are well known for producing unique secondary metabolites, some of which have been shown to exhibit medically relevant bioactivities, including antimicrobial effects. With the increasing prevalence of fungal infections and the growing resistance to commonly used antimycotics, there is an urgent need for new antifungal agents, especially for aged and/or immunocompromised individuals. In this study, we screened a collection of lichen-derived metabolites for antifungal properties in two medically relevant fungal pathogens, Candida albicans and Nakaseomyces glabratus. Several compounds exhibited inhibitory effects against planktonic cells and/or biofilm formation in at least one of these species. Notably, two related paraconic acids demonstrated the strongest activity aga

SUBMITTER: Odabas MN 

PROVIDER: S-EPMC12832668 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature