Epidemiological trends of infant mortality related to premature rupture of membranes: U.S. 1999-2023.

ABSTRACT:

Introduction

Premature rupture of membranes (PROM) complicates 8% of pregnancies and accounts for nearly one-third of preterm labor. While prior studies have examined clinical management and maternal risk factors, national data on PROM-related infant mortality remains scarce. This study investigates demographic trends in PROM-related infant mortality in the U.S. from 1999 to 2023.

Methods

The CDC WONDER database was utilized to identify U.S. crude mortality rates of newborns affected by PROM (ICD-10 code P01.1). Demographic variables were analyzed through the CDC Joinpoint Regression program to evaluate temporal trends. This study used publicly available, de-identified data and is IRB-exempt.

Results

A total of 27,184 PROM-related infant deaths were identified from 19

SUBMITTER: Eason L 

PROVIDER: S-EPMC12832673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature