Antigenic assessment for the β2-glycoprotein I/Platelet factor 4 complex in thrombotic patients with antiphospholipid syndrome.

ABSTRACT:

Objective

Antiphospholipid syndrome (APS) is an autoimmune condition characterized by recurrent thrombosis, pregnancy-related complications and circulating antiphospholipid antibodies, including anti-β2-glycoprotein I (β2-GPI). Platelet factor 4 (PF4) is a pro-coagulant protein expressed by activated platelets. It is considered a potential platelet ligand for oxidized β2-GPI, and this interaction may play a role in the thrombotic manifestations of APS. This study aims to assess β2-GPI/PF4 complex autoantibodies in sera of thrombotic patients with APS and their potential functional role in platelet activation.

Methods

We analysed sera from 73 patients with thrombotic APS, 20 with obstetric APS, 20 with systemic lupus erythematosus (SLE), 20 with non-APS thrombosis, 3 with vac

SUBMITTER: Villani F 

PROVIDER: S-EPMC12832691 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature