Impact of intraoperative packed red blood cell transfusion volume on prognosis in CRS: a propensity-matched study.

ABSTRACT:

Background

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal metastasis but is associated with significant blood loss requiring intraoperative red blood cell (RBC) transfusion. Evidence suggests transfusions may impair immunity and worsen oncologic outcomes, yet the prognostic impact of intraoperative packed RBC transfusion (iPRBT), especially transfusion volume, in CRS/HIPEC remains unclear.

Methods

We conducted a single-center, retrospective study of 128 patients with advanced peritoneal metastasis who underwent CRS with intraoperative RBC transfusion between January 2018 and December 2024. Patients were stratified into low transfusion (≤4 units) and high transfusion (>4 units) groups. Propensity sco

SUBMITTER: Li J 

PROVIDER: S-EPMC12832702 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature