Total outflow facility before and after goniotomy in ex vivo perfusion models for aqueous humor dynamics: effect of periocular tissue.

ABSTRACT:

Background

Ex vivo perfusion models to simulate aqueous humor dynamics are commonly used to test interventions for glaucoma treatment. Many models, however, overestimate the effect of surgical interventions. Periorbital tissue is routinely removed during the experimental preparation. Evidence suggests that up to 50% of total outflow resistance is attributable to the distal outflow pathways. It is currently unclear if varying degrees of tissue removal alone elicit changes in total outflow facility (C_tot). We compared C_tot in whole globes with and without preserved periorbital tissue with intact trabecular meshwork (TM) and with surgical TM bypass in an ex vivo perfusion model.

Methods

A total of 33 post-mortem porcine eyes with intact surro

SUBMITTER: Kallab M 

PROVIDER: S-EPMC12832705 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature