Black phosphorus-doped silk fibroin coating improves osteogenesis for ameliorative graft-bone healing of polyethylene terephthalate artificial ligaments.

ABSTRACT: This study aimed to investigate the effect of black phosphorus-doped silk fibroin (BP/SF) coating on graft-bone healing of artificial ligaments made from polyethylene terephthalate (PET). A BP/SF-coated PET artificial ligament (BP/SF-PET) was prepared, and its surface characteristics were examined using transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The cytocompatibility and osteogenic induction ability of the BP/SF-PET ligaments were evaluated in vitro. In addition, uncoated PET (PET group, n = 15) and BP/SF-coated PET (BP/SF-PET group, n = 15) artificial ligaments were randomly applied for anterior cruciate ligament reconstruction in rabbits. Micro-computed tomography (CT), and histological, immunoflu

SUBMITTER: Wei J 

PROVIDER: S-EPMC12832776 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature