Depression mediates motor dysfunction's effect on sleep quality in ALS: a mediation analysis study.

ABSTRACT:

Introduction

Poor sleep quality affects 50-63% of Amyotrophic lateral sclerosis (ALS) patients, exacerbating disease burden and reducing quality of life. This study aimed to investigate the relationships among disease severity, depressive symptoms, and sleep quality in ALS, with a focus on the mediating effects of depression.

Methods

Our study enrolled 408 ALS patients. Disease severity was assessed using the ALS Functional Rating Scale-Revised (ALSFRS-R), sleep quality via the Pittsburgh Sleep Quality Index (PSQI), and psychological status using the Hamilton Depression (HAMD) and Anxiety (HAMA) scales. Statistical analyses included Spearman correlations, multivariate regression, and mediation analysis (Hayes' PROCESS macro).

Results

Poor sleep quality (PSQI > 5) was

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12832777 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature