Expression and clinical significance of platelet-derived miR-145-5p and miR-6805-3p in diabetic kidney disease patients.

ABSTRACT:

Objectives

Approximately 30-40% of diabetes mellitus (DM) patients will progress to diabetic kidney disease (DKD) and eventually cause end-stage renal disease (ESRD) during their disease course; therefore, early recognition and prevention of DKD is critical. The detection based on biomarkers derived from blood samples has the characteristics of easy availability and affordability. In addition to participating in thrombosis and hemostasis, platelets also have important secretion functions. Our research aims to identify novel platelet miRNA candidates for DKD diagnosis and to explore their clinical significance.

Methods and results

miR-145-5p and miR-6805-3p were selected for further evaluation based on their differentially expressed status between DM and DKD subjects, as dete

SUBMITTER: Hu M 

PROVIDER: S-EPMC12832840 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature